• Login
    • Login
    Advanced Search
    View Item 
    •   AMREF IR Home
    • Research Papers
    • General - GEN
    • General - GEN
    • View Item
    •   AMREF IR Home
    • Research Papers
    • General - GEN
    • General - GEN
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Chlorproguanil/Dapsone for the Treatment of Non-severe Plasmodium Falciparum Malaria in Kenya: a pilot study

    Thumbnail
    View/Open
    Abstract (1.209Mb)
    Publication Date
    5/1/1988
    Authors
    Watkins, W.M.
    Brandling-Bennett, A.D.
    Nevill, C.G.
    Carter, J.Y.
    Boriga, D.A.
    Howells, R.E.
    Koech, D.K.
    Show More
    (7 total)
    Type
    Article, Journal
    Item Usage Stats
    6
    views
    1
    downloads
    Metadata
    Show full item record
    Citation

    Watkins WM, Brandling-Bennett AD, Nevill CG, Carter JY, Boriga DA, Howells RE, Koech DK. Chlorproguanil/dapsone for the treatment of non-severe Plasmodium falciparum malaria in Kenya: a pilot study. Trans R Soc Trop Med Hyg. 1988;82(3):398-403. doi: 10.1016/0035-9203(88)90133-2. PMID: 3068855.

    Abstract/Overview

    Chlorocycloguanil, the active metabolite of chlorproguanil, was synergistic in vitro with dapsone against 2 culture-adapted Plasmodium falciparum isolates from Kenya; maximal synergy occurred at lower concentrations that it did with pyrimethamine and sulfadoxine. 48 children with asymptomatic P. falciparum infections were treated with chlorproguanil (at a target dose of 1·2 mg/kg) and dapsone (target dose of 1·2 or 2·4 mg/kg); all were free of parasitaemia by day 7. The following numbers had recurrences on days 14, 21, and 28, respectively: 1 of 48, 7 of 47, and 7 of 40. All 39 children treated with pyrimethamine (target dose 1·2 mg/kg) and sulfadoxine (target dose 24 mg/kg) were cleared of infection, while the following had recurrences on days 14, 21, and 28:1 of 39, 2 of 38, and 2 of 36. The rate of decrease in parasitaemia was the same in the 2 groups, and there was no change in haematocrit or haemoglobin during the follow-up. The rate of recurrence in the children receiving chlorporguanil/dapsone was higher, probably because these drugs have a much shorter clearance time than pyrimethamine/sutfadoxine. Chlorproguanil/dapsone is an effective combination for treating P. falciparum malaria and deserves further study.

    Subject/Keywords
    Metabolite; Kenya; pyrimethamine and sulfadoxine; Parasitaemia; Haemoglobin; Malaria
    Further Details

    Restricted

    Publisher
    Oxford University Press
    Permalink
    http://repository.amref.org/handle/123456789/191
    Collections
    • General - GEN [355]

    Amref International University. All rights reserved | Copyright © 2021 
    Contact Us | Send Feedback

     

     

    Quick Links
    Amref International UniversityAmref Health AfricaKLISC

    Browse

    All of AMREF IRCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsType

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Amref International University. All rights reserved | Copyright © 2021 
    Contact Us | Send Feedback