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    Daily chlorproguanil is an effective alternative to daily proguanil in the prevention of Plasmodium falciparum malaria in Kenya

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    Research article (303.6Kb)
    Publication Date
    8/5/1993
    Authors
    Nevill, C. G.
    Lury, J. D.
    Mosobo, M. K.
    Watkins, H. M.
    Watkins, W. M.
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    (5 total)
    Type
    Article, Journal
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    Citation

    Nevill CG, Lury JD, Mosobo MK, Watkins HM, Watkins WM. Daily chlorproguanil is an effective alternative to daily proguanil in the prevention of Plasmodium falciparum malaria in Kenya. Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):319-20. doi: 10.1016/0035-9203(94)90100-7. PMID: 7974677.

    Abstract/Overview

    To test the efficacy of chlorproguanil prophylaxis, 156 malaria-free schoolchildren in the coastal region of Kenya were allocated at random to receive either 7.5 mg chlorproguanil daily, 50 mg chlorproguanil weekly, 100 mg proguanil daily, or 100 mg calcium lactate weekly (placebo). The children were followed up daily for 169 d, by which time Plasmodium falciparum parasitaemia had occurred in 92% of the placebo group, 3 1% of the daily proguanil group, 38% of the daily chlorproguanil group and 55% of the weekly chlorproguanil group. There was significant reduction (P<O.OOl) in the risk of parasitaemia in all the groups receiving chemoprophylaxis. Daily chlorprognanil and daily proguanil were equally effective, and significantly more effective than weekly high dose chlorproguanil. No significant toxicity was reported or observed. Thus daily chlorproguanil20 mgi60 kg is a cheap and effective alternative to proguanil for chemoprophylaxis.

    Subject/Keywords
    Prophylaxis; Malaria; Placebo; Toxicity; Chemoprophylaxis; Kenya
    Publisher
    Transitional of the Royal Society of Tropical Medicine and Hygiene
    ISSN
    0035-9203
    Permalink
    http://repository.amref.org/handle/123456789/193
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    • General - GEN [355]

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