dc.contributor.author | Domman, Daryl | |
dc.contributor.author | Njamkepo, Elisabeth | |
dc.contributor.author | Almesbahi, Abdullrahman A. | |
dc.contributor.author | Naji, Mona | |
dc.contributor.author | Nasher, Samar Saeed | |
dc.contributor.author | Rakesh, Ankur | |
dc.contributor.author | Assiri6, Abdullah M. | |
dc.contributor.author | Sharma, Naresh Chand | |
dc.contributor.author | Kariuki, Samuel | |
dc.contributor.author | Pourshafie, Mohammad Reza | |
dc.contributor.author | Abubakar, Abdinasir | |
dc.contributor.author | Carter, Jane Y. | |
dc.contributor.author | Wamala, Joseph F. | |
dc.contributor.author | Seguin, Caroline | |
dc.contributor.author | Bouchier, Christiane | |
dc.contributor.author | Malliavin, Thérèse | |
dc.contributor.author | Bakhshi, Bita | |
dc.contributor.author | Abulmaali, Hayder H. N. | |
dc.contributor.author | Kumar, Dhirendra | |
dc.contributor.author | Njoroge, Samuel M. | |
dc.contributor.author | Malik, Mamunur Rahman | |
dc.contributor.author | Kiiru, John | |
dc.contributor.author | Luquero, Francisco J. | |
dc.contributor.author | Azman, Andrew S. | |
dc.contributor.author | Ramamurthy, Thandavarayan | |
dc.contributor.author | Thomson, Nicholas R. | |
dc.contributor.author | Quilici, Marie-Laure | |
dc.contributor.author | Weill, François-Xavier | |
dc.date.accessioned | 2022-01-26T14:00:47Z | |
dc.date.available | 2022-01-26T14:00:47Z | |
dc.date.issued | 2019-09-20 | |
dc.identifier.citation | Weill, François-Xavier & Domman, Daryl & Njamkepo, Elisabeth & Almesbahi, Abdullrahman & Naji, Mona & Nasher, Samar & Rakesh, Ankur & Assiri, Abdullah & Sharma, Naresh C & Kariuki, Sam & Pourshafie, Mohammad & Rauzier, Jean & Abubakar, Abdinasir & Carter, Jane & Wamala, Joseph & Seguin, Caroline & Bouchier, Christiane & Malliavin, Thérèse & Bakhshi, Bita & Quilici, Marie-Laure. (2019). Genomic insights into the 2016–2017 cholera epidemic in Yemen. Nature. 565. 10.1038/s41586-018-0818-3. | en_US |
dc.identifier.other | DOI: 10.1038/s41586-018-0818-3 | |
dc.identifier.uri | https://repository.amref.ac.ke/handle/123456789/531 | |
dc.description.abstract | Yemen is currently experiencing, to our knowledge, the largest
cholera epidemic in recent history. The first cases were declared
in September 2016, and over 1.1 million cases and 2,300 deaths
have since been reported1. Here we investigate the phylogenetic
relationships, pathogenesis and determinants of antimicrobial
resistance by sequencing the genomes of Vibrio cholerae isolates
from the epidemic in Yemen and recent isolates from neighbouring
regions. These 116 genomic sequences were placed within the
phylogenetic context of a global collection of 1,087 isolates of the
seventh pandemic V. cholerae serogroups O1 and O139 biotype El
Tor2–4. We show that the isolates from Yemen that were collected
during the two epidemiological waves of the epidemic1—the first
between 28 September 2016 and 23 April 2017 (25,839 suspected
cases) and the second beginning on 24 April 2017 (more than
1 million suspected cases)—are V. cholerae serotype Ogawa
isolates from a single sublineage of the seventh pandemic V. cholerae
O1 El Tor (7PET) lineage. Using genomic approaches, we link the
epidemic in Yemen to global radiations of pandemic V. cholerae
and show that this sublineage originated from South Asia and
that it caused outbreaks in East Africa before appearing in Yemen.
Furthermore, we show that the isolates from Yemen are susceptible
to several antibiotics that are commonly used to treat cholera and
to polymyxin B, resistance to which is used as a marker of the El
Tor biotype. | en_US |
dc.publisher | ResearchGate | en_US |
dc.title | Genomic insights into the 2016–2017 cholera epidemic in Yemen | en_US |
dc.type | Article, Journal | en_US |