Key aspects defining the development and implementation of a regional genomic surveillance strategy for the Eastern Mediterranean Region

Abstract

The COVID-19 pandemic highlighted the critical role of pathogen sequencing in mak ing informed public health decisions. Initially, the Eastern Mediterranean Region faced limitations in sequencing capacity. However, with robust WHO and stake holder support, the situation significantly improved. By 2022, COVID-19 sequencing was underway in 22 out of 23 regional countries, with varying throughput and capac ity. Notably, three genomic hubs were established in Oman, UAE, and Morocco, play ing a key role in providing expanded genomics training and support across the region. While primarily for COVID-19 surveillance, this sequencing capacity offers an opportunity to integrate genomic surveillance into existing networks. This integration can enable early detection and response to high-threat pathogens with pandemic potential. To advance this, WHO/EMRO collaborated with stakeholders to formulate the Eastern Mediterranean Regional Genomic Surveillance Strategy for Emerging Pathogens of Pandemic Concern. Consultative meetings with regional and interna tional genomic surveillance experts identified strategy focal points, key partners, pri ority pathogens, and implementation steps. As the strategy awaits member states’ ratification in Q4 2023, this manuscript outlines pivotal facets defined by member states and the strategic document’s key deliverables and opportunities. These efforts aim to yield a substantial positive impact within the region.