Daily chlorproguanil is an effective alternative to daily proguanil in the prevention of Plasmodium falciparum malaria in Kenya
Daily chlorproguanil is an effective alternative to daily proguanil in the prevention of Plasmodium falciparum malaria in Kenya
Date
Authors
Nevill, C. G.
Lury, J. D.
Mosobo, M. K.
Watkins, H. M.
Watkins, W. M.
Type
Article, Journal
Journal Title
Journal ISSN
Volume Title
Publisher
Transitional of the Royal Society of Tropical Medicine and Hygiene
Type
Article, Journal
Abstract
To test the efficacy of chlorproguanil prophylaxis, 156 malaria-free schoolchildren in the coastal region of Kenya were allocated at random to receive either 7.5 mg chlorproguanil daily, 50 mg chlorproguanil weekly, 100 mg proguanil daily, or 100 mg calcium lactate weekly (placebo). The children were followed up daily for 169 d, by which time Plasmodium falciparum parasitaemia had occurred in 92% of the placebo group, 3 1% of the daily proguanil group, 38% of the daily chlorproguanil group and 55% of the weekly chlorproguanil group. There was significant reduction (P
Description
Keywords
Prophylaxis, Malaria, Placebo, Toxicity, Chemoprophylaxis, Kenya
Citation
Nevill CG, Lury JD, Mosobo MK, Watkins HM, Watkins WM. Daily chlorproguanil is an effective alternative to daily proguanil in the prevention of Plasmodium falciparum malaria in Kenya. Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):319-20. doi: 10.1016/0035-9203(94)90100-7. PMID: 7974677.