Browsing Books and Book Chapters by Subject "Extensive metabolizers (EM)"

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Variability in the Metabolism of Proguanil to the Active Metabolite Cycloguanil in Healthy Kenyan Adults

Watkins, W.M.; Mberu, E.K.; Nevill, C.G.; Ward, S.A.; Breckenridge, A.M.; Koech, D.K. (Oxford University Press, 1990-08-01)

Extensive metabolizers (EM) and poor metabolizers (PM) of the malaria chemoprophylactic drug proguanil have been identified by measuring the proguanil/cycloguanil ratio in urine following a single dose of the pro-drug. The ...