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Variability in the Metabolism of Proguanil to the Active Metabolite Cycloguanil in Healthy Kenyan Adults
(Oxford University Press, 1990-08-01)
Extensive metabolizers (EM) and poor metabolizers (PM) of the malaria chemoprophylactic drug proguanil have been identified by measuring the proguanil/cycloguanil ratio in urine following a single dose of the pro-drug. The ...