• Login
    • Login
    Advanced Search
    View Item 
    •   AMREF IR Home
    • Research Papers
    • Library
    • Peer-Reviewed Articles
    • View Item
    •   AMREF IR Home
    • Research Papers
    • Library
    • Peer-Reviewed Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    A case-control study on risk factors for visceral leishmaniasis in West Pokot County, Kenya

    Thumbnail
    View/Open
    Tropical Med Int Health - 2024 - Dijk - A case control study on risk factors for visceral leishmaniasis in West Pokot.pdf (643.5Kb)
    Publication Date
    2024-10-29
    Authors
    Dijk, Norbert
    Carter, Jane
    Kiptanui, David
    Mens, Petra F
    Schallig, Henk D F H
    Show More
    (5 total)
    Type
    Article, Journal
    Item Usage Stats
    4
    views
    1
    downloads
    Metadata
    Show full item record
    Citation

    van Dijk NJ, Carter J, Kiptanui D, Mens PF, Schallig HDFH. A case-control study on risk factors for visceral leishmaniasis in West Pokot County, Kenya. Trop Med Int Health. 2024 Oct;29(10):904-912. doi: 10.1111/tmi.14049. Epub 2024 Sep 4. PMID: 39229674.

    Abstract/Overview

    Background: Visceral leishmaniasis (VL) is a severe parasitic disease transmitted by phlebotomine sandflies. VL is endemic in West Pokot County, Kenya, where effective strategies to interrupt transmission are impeded by the limited understanding of VL risk factors. Therefore, this case-control study aimed to explore environmental, behavioural and household determinants of VL in West Pokot. Methods: From November 2022 to January 2023, a structured questionnaire was administered to 36 symptomatic primary VL cases attending Kacheliba Sub-County Hospital in West Pokot and to 50 healthy controls from local villages. The VL status of all participants was confirmed using an rK39 rapid diagnostic test. Associations between questioned determinants and VL were investigated by means of age-corrected univariate logistic regression analysis. Results: Significant associations were found between VL and housing characteristics, such as window presence and floor type. VL cases more frequently reported the presence of cattle, dogs and sheep in their house yards. VL was also associated with cutting down trees in the house yard and house proximity to several Acacia tree species. Furthermore, outdoor activities, including travelling outside the residence for more than 2 weeks, activities near termite mounds, and forest activities during the rainy season, increased the risk of VL. Conclusions: This work reports a number of previously undescribed risk factors for VL in the understudied West Pokot focus. The results suggest VL transmission occurs both peri-domestically at night and outdoors during the day, particularly when sandfly resting sites are disturbed. Our findings warrant further research into sandfly ecology and potential zoonotic parasite reservoirs in West Pokot.

    Subject/Keywords
    Kenya; case–control study; risk factors; sandfly; visceral leishmaniasis
    Further Details

    DOI: 10.1111/tmi.14049

    Publisher
    Trop Med Int Health
    Permalink
    https://repository.amref.ac.ke/handle/20.500.14173/989
    Collections
    • Peer-Reviewed Articles [29]

    Amref International University. All rights reserved | Copyright © 2021 
    Contact Us | Send Feedback

     

     

    Quick Links
    Amref International UniversityAmref Health AfricaKLISC

    Browse

    All of AMREF IRCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsType

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Amref International University. All rights reserved | Copyright © 2021 
    Contact Us | Send Feedback